Dr Burcu Tepekule appointed as BRCCH Professor of Paediatric Infectious and Emerging Diseases Modelling

Dr Burcu Tepekule appointed as BRCCH Professor of Paediatric Infectious and Emerging Diseases Modelling

In August 2026, Dr Burcu Tepekule will join the Basel Research Centre for Child Health (BRCCH) as a Tenure-Track Assistant Professor in Paediatric Infectious and Emerging Diseases Modelling. She will be affiliated with the Department of Biomedical Engineering of the University of Basel, where she will investigate how children’s health is shaped by the interactions between the immune system and the gut microbiota during the first years of life.

 

Dr Tepekule’s research explores how early-life environmental perturbations such as malnutrition, infection or antibiotic exposure influence immune maturation. Using mathematical models informed by paediatric cohort data, her research group will characterise how early-life immune imprinting influences infectious disease susceptibility and vaccine response in children. Ultimately, her research will contribute to the generation of microbiome-targeted interventions at the population scale to prevent pathological immune programming, thereby improving lifelong health outcomes for children across diverse socioeconomic and geographical settings.

Seminar – Bridging Early Detection and Innovation in Adolescent Mental Health: Current Research & Emerging Digital Solutions

Seminar - Bridging Early Detection and Innovation in Adolescent Mental
Health: Current Research & Emerging Digital Solutions

 

The BRCCH cordially invites you to join a seminar on mental health of young populations. During this talk, three experts in psychology and neuroscience will share with us how digital technology is currently supporting the early diagnosis and treatment of adolescents affected by mental health conditions.

When: Monday, 24 November 2025, 16:00 - 17:30 CET

Where:  Hybrid Zoom / Seminar room U1.193– Biozentrum, University of Basel, Spitalstrasse 41, 4056 Basel

Directions and location information

Zoom Registration: HERE

In Person Registration: HERE

Schedule:

      • Keynote by Dr Dorothée Bentz (University of Basel): "From Virtual Reality to Online Interventions: Harnessing Technology to address common mental health challenges in young populations"
      • Keynote by Dr Marc Birkhölzer (Universitäre psychiatrische
        Dienste Bern): "The EARLY Study: Investigating early signs, risk factors and developmental course of personality functioning impairment in young people – an international multicenter longitudinal study – initial findings and current status"
      • Keynote by Ana Gregorec (University Medical Center
        Maribor, Slovenia): "Adolescent Personality Disorders in Slovenia: The EARLY Study, Other Ongoing Research and Current Diagnostic Practice"
      • Q&A and Closing

Speakers:

Dr Dorothée Bentz

University of Basel, Switzerland

Profile

PD Dr Dorothée Bentz is a translational psychotherapy researcher with a dual background in clinical psychology and cognitive neuroscience. Her work aims to close gaps in mental health care by developing evidence-based interventions, integrating new technologies, applying translational methods, and identifying new points of intervention through targeted applied basic research.

Dr Dorothée Bentz co-leads the BRCCH project "EARLY: Investigating Early Signs and Developmental Course of Personality Disorders in Young People." Read more here.

Dr. Marc Birkhölzer

Universitäre psychiatrische Dienste Bern

Profile

Dr Marc Birkhölzer is a psychiatrist at the University of Basel and a senior physician in the Juvenile Forensic Department at University Psychiatric Clinics Basel. His research focuses on personality disorders. Over the years, he has built an extraordinary network of collaborators in countries all over the world.

Dr Marc Birkhölzer leads the BRCCH project "EARLY: Investigating Early Signs and Developmental Course of Personality Disorders in Young People." Read more here.

Ana Gregorec

University Medical Center Maribor, Slovenia

Profile

Ana Gregorec is a PhD candidate in Developmental Psychological Studies and a clinical psychology resident. She works at the University Clinical Center Maribor (Slovenia), Division of Pediatrics, Unit for Child and Adolescent Psychiatry. Her research focuses on personality pathology in adolescents, emphasizing early signs and developmental pathways beginning in childhood. Her work aims to clarify the transdiagnostic clinical value of new dimensional models of personality disorders.

Ana Gregorec is a Researcher in the BRCCH project "EARLY: Investigating Early Signs and Developmental Course of Personality Disorders in Young People." Read more here.

Inaugural Lecture – Genetics of depression: from statistical associations to molecular understanding

Inaugural Lecture, 17 November 2025 - Genetics of depression: from statistical associations to molecular understanding

 

The BRCCH cordially invites you to the inaugural lecture of Prof Na Cai, who holds a BRCCH professorship in Computational Medical Genomics at ETH Zurich. In her talk, Prof Na Cai will discuss the genetic factors underlying major depression disorder, a condition afflicting children and adolescents worldwide and still without reliable diagnostics or effective treatment. In addition, she will describe the future directions of her research, from innovative methodologies for mining biobanks and electronic health records to the use of combined molecular, clinical and environmental data to uncover the heterogeneity behind depression’ causes.

When: Monday, 17th November 2025, 16:00 - 17:30 CET, to be followed by an apéro

Where: Hybrid Zoom / ETH Zurich, D-BSSE, Lecture Hall E27, Klingelbergstrasse 48, 4056 Basel.

See map

Zoom Registration: HERE

In Person Registration: HERE

Schedule:

      • Welcome by Prof Daniel Müller, Co-Director of the BRCCH and Prof Sven Panke, Head of D-BSSE, ETH Zurich
      • Lecture delivered by Prof Na Cai, ETH Zurich, Switzerland: "Genetics of depression: from statistical associations to molecular understanding"
      • Q&A and Closing
      • Networking Apéro

Speaker:

Prof Na Cai

ETH Zurich, Switzerland

Talk: "Genetics of depression: from statistical associations to molecular understanding"

Profile: Prof Dr Na Cai is the BRCCH Professor in Computational Medical Genomics. She is a statistical geneticist and her work focuses on the genetic underpinnings of psychiatric disorders, in particular major depression disorder. Prof Na Cai obtained her PhD at the Welcome Trust Centre for Human Genetics at the University of Oxford and continued with her postdoctoral studies at the Welcome Sanger Institute and EMBL's European Bioinformatics Institute. Before moving to the Department of Biosystems Science and Engineering of ETHZ, she led her own research group at Helmholtz Munich.

Watch the presentation on YouTube here.

Seminar – Digital Approaches in Respiratory Research and Clinical Practice

Seminar 29 October 2025 - Digital Approaches in Respiratory Research and Clinical Practice

 

The BRCCH cordially invites you to join a seminar on digital approaches in respiratory research and clinical practice. During this talk, we will learn about the challenges faced by caregivers and clinicians when presented with paediatric pneumonia and asthma and how artificial intelligence (AI) has the potential to create innovative solutions for the diagnosis and treatment of both diseases.

When: Wednesday, 29 October 2025, 16:00 - 17:30 CET

Where:  Seminar room U1.195– Biozentrum, University of Basel, Spitalstrasse 41, 4056 Basel

Registration: HERE

Directions and location information

Schedule:

      • Keynote by Prof Edgar Delgado-Eckert (University of Basel): "Applications of unsupervised and supervised learning in respiratory research"
      • Keynote by Prof Ioana M. Ciuca (Victor Babes University of Medicine and Pharmacy, Romania): "AI and lung ultrasound in children pneumonia"
      • Keynote by Prof Mihai Craiu (University of Medicine and Pharmacy "Carol Davila", Romania): "Real life educational aspects of asthma management in children from Romania"
      • Q&A and Closing

Speakers:

Prof Edgar Delgado-Eckert

University of Basel, Switzerland

Profile

Prof Edgar Delgado-Eckert is an adjunct professor in the Department of Biomedical Engineering at the University of Basel and a research group leader at University Children’s Hospital Basel (UKBB). His work is devoted to scientific research and also to teaching and mentoring students and postdoctoral researchers.

Prof Delgado-Eckert’s research interests revolve around applications of mathematical modelling, computer simulation and statistical analysis to biological and biomedical problems. He has used such computational approaches in order to study fundamental problems in the fields of virology, immunology and epidemiology, and he has also worked on questions concerning human (patho-)physiology with potential clinical implications, particularly in the field of respiratory medicine.

Prof Delgado-Eckert began his career at the Technical University of Munich, Germany, where he completed a master’s degree in mathematics with a minor in physics. He then moved to the USA, where he conducted his PhD research at Virginia Tech and the Tufts University Medical School in Boston. After completing his PhD, he became a postdoctoral researcher in the Department of Biosystems Science and Engineering (D-BSSE) at ETH Zurich. He was then awarded a Marie Skłodowska-Curie Postdoctoral Fellowship from the European Commission.

Prof Edgar Delgado-Eckert leads the BRCCH project: Alex: Design, Development and Evaluation of a Digital Health Assistant for Paediatric Asthma. Read more here.

Prof Ioana Mihaiela Ciuca

Victor Babes University of Medicine and Pharmacy, Timisoara, Romania

Profile

Prof Ioana Ciuca, PhD, is a member of the Department of Pediatrics at the Victor Babeş University of Medicine and Pharmacy Timisoara, Romania, and the Coordinator of the Pediatric Pneumology Training Programme. She is also a consultant paediatrician and the current Head of the Paediatric Pulmonology Unit at Clinical County Hospital Timisoara and is certified in paediatric respiratory medicine. She is the Vice President of the Romanian National Cystic Fibrosis Society and a member of several scientific societies, including the European Respiratory Society, the Romanian Society of Pulmonology, the European Society of Human Genetics and the Romanian Paediatric Society.

Prof Ciuca has written papers on paediatric respiratory medicine and has participated in studies of cystic fibrosis, including the European Centers of Reference Network for Cystic Fibrosis (ECORN-CF). She has also received five bursaries for training programmes and courses from the European Respiratory Society and three awards for the best poster presented at the Congress of International Pediatric Pulmonology (2019, 2022) and the King’s John Price Paediatric Respiratory Conference in London (2019). She is actively involved in the development of Romania’s paediatric pulmonology training programme. Her special interests are lung ultrasound, cystic fibrosis, asthma, child pneumonia, chronic cough and preschool wheezing.

Prof Ioana M. Ciuca is a Collaborator in the BRCCH project: Alex: Design, Development and Evaluation of a Digital Health Assistant for Paediatric Asthma. Read more here.

Prof Mihai Craiu

University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania

Profile

Prof Mihai Craiu is currently an associate professor at Carol Davila Medical School, Bucharest, Romania. He is a highly accomplished medical professional with a wealth of experience in the field of paediatrics and respiratory medicine. Prof Craiu has dedicated his career to improving paediatric healthcare and to the education of future healthcare professionals.

Currently serving as the Head of the Second Paediatric Clinic at Carol Davila Medical School in Bucharest, Romania, Prof Mihai Craiu has been actively engaged in various clinical and educational activities. He manages clinic operations, provides lectures to medical students in both Romanian and English modules, and imparts practical training in paediatric emergencies. His expertise extends to Paediatric Advanced Life Support (PALS) training and the coordination of residents in the Emergency Department.

With a strong emphasis on teaching and research, Prof Craiu has contributed significantly to the medical community. He has published numerous papers and conducted clinical trials, particularly in the field of paediatric respiratory diseases.

Overall, Prof Craiu's career exemplifies a deep commitment to paediatric care, education, and research, making him a highly respected figure in the medical field.

Prof Mihai Craiu is a Collaborator in the BRCCH project: Alex: Design, Development and Evaluation of a Digital Health Assistant for Paediatric Asthma. Read more here.

BRCCH Course on Foundations of Paediatric Digital Health

BRCCH Course on Foundations of Paediatric Digital Health

 

How has the digital health revolution influenced paediatric care? Which digital interventions are suitable for improving the health and well-being of children and adolescents?

During this free course taught by experts from the Digital Health Unit at the Swiss Tropical and Public Health Institute, participants will explore the opportunities and challenges associated with the implementation of digital technologies for paediatric care. The course will be delivered through a blended approach, which consists of an online self-directed phase with preparatory materials followed by two half-day in-person sessions. At the end of the course, participants will be familiar with how to design, implement and evaluate digital health interventions for the paediatric population.

Date: Monday 6 and Tuesday 7 October 2025

Time: 12:30 - 16:30 (CET)

Location: BRCCH offices at Petersgraben 31, 4051 Basel, Switzerland

Registration: Please register HERE. The two-day course will only be delivered in person. The deadline for registration is 12:00 (CET) on 26 September. Registrations from those interested only in the online materials will not be accepted.

 

Course Objectives:

    • Develop a broad understanding of the digital ecosystem and the role of digital technology in supporting improvements in paediatric health and well-being
    • Critically explore potential benefits and risks of digital health for the paediatric population
    • Learn approaches to user- and system-centred design of digital health interventions
    •  Be able to identify key objectives and appropriate methodologies for evaluating digital health interventions at different stages of development
    • Examine ethical considerations and regulatory requirements for paediatric digital health interventions and research
    • Develop and apply critical analysis skills relevant to paediatric digital health through analysis of real-world case studies

Course Programme:

    • Introduction to digital health (definitions, WHO classification) and digital health interventions relevant to children and their caregivers, healthcare providers and health system managers
    • Key Artificial Intelligence concepts relevant to paediatric digital health
    • Approach to digital development
    • Digital health evaluation objectives across the stages of intervention maturity
    • Acceptability and usability of digital health interventions
    • Efficacy and effectiveness evaluation
    • Economic and sustainability evaluation
    • Understanding the use of real-world data for evaluating digital health interventions
    • Ethical and regulatory considerations for paediatric digital health

Additional topics may be covered during the sessions, depending on the background and interests of specific individuals participating in the course.

 

Seminar – Evidence in focus: using visual analytics to shape the future of insecticide-treated nets procurement

Seminar 15 September 2025 - Evidence in focus: using visual analytics to shape the future of insecticide-treated nets procurement

 

The BRCCH cordially invites you to join a seminar in which experts from the Swiss Tropical and Public Health Institute (STPH) will discuss the challenges and latest advancement of one of the most effective malaria prevention method, the insecticide-treated net (ITN). Over three lectures, the speakers will discuss the cost-effectiveness of this method, how to integrate computational methods to enhance the efficiency of ITNs, and the limitations associated with ITNs distribution.

When: Monday, 15th September 2025, 16:00 - 17:30 CET, followed by an apero

Where:  Hybrid Zoom / Seminar room 5 – Swiss Tropical and Public Health Institute, Kreuzstrasse 2, 4123 Allschwil

Zoom Registration: HERE

In Person Registration: HERE
Directions and location information

Schedule:

      • Keynote by Prof Sarah Moore (Swiss TPH): "Choosing wisely: cost-effectiveness as a driver for vector control innovation"
      • Keynote by Prof Philippe Cattin (University of Basel, Switzerland): "Artificial intelligence - based analysis of mosquito net digital photographs for automated monitoring"
      • Keynote by Emmanuel Mbuba (Swiss TPH): "Evaluating the durability of ultra-long lasting insecticidal nets: field progress and emerging insights"
      • Q&A and Closing
      • Networking Apéro

Watch on Youtube

Speakers:

Prof Sarah Moore

Swiss TPH, Allschwil, Switzerland

Profile

Prof Sarah Moore is a medical entomologist and group leader in the Vector Biology Unit at the Swiss Tropical and Public Health Institute (Swiss TPH). For the last 15 years, she has been based at the Ifakara Health Institute (IHI) in Tanzania, where she leads the IHI Vector Control Product Testing Unit, which conducts laboratory studies, field trials and large-scale evaluations of interventions designed to protect individuals and communities from vector-borne diseases. Her research interests are focused on developing new and efficient ways to evaluate novel vector control technologies and on training the next generation of medical entomologists to tackle vector-borne diseases in a rapidly changing world.

Prof Sarah Moore leads the BRCCH project: ViALLIN: Visual Analysis of Long Lasting Insecticidal Nets to Maximise Universal Access. Read more here.

Prof Philippe Cattin

University of Basel, Switzerland

Profile

Prof Philippe Cattin received his MSc in computer science in 1995 and his PhD in robotics in 2003 from ETH Zurich, where he was a postdoctoral fellow at the Computer Vision Laboratory (CVL) from 2003 to 2007. In 2007, he became an assistant professor at the University of Basel, where he was promoted to associate professor in 2015 and then to full professor in 2019. He is the founding and current Head of the Department of Biomedical Engineering at the University of Basel. In 2017, he was a research fellow at Brigham and Women’s Hospital in Boston, USA.

Prof Cattin’s research interests include medical image analysis, image-guided therapy, robotics-guided laser osteotomy and virtual reality. As a principal investigator, he has completed many projects in these areas and has published over 250 papers, patents and book chapters. He is also the founder of three spin-off companies and has licensed his patents and software to medical device companies.

Prof Philippe Cattin co- leads the BRCCH project: ViALLIN: Visual Analysis of Long Lasting Insecticidal Nets to Maximise Universal Access. Read more here.

Emmanuel Mbuba

Swiss TPH, Allschwil, Switzerland

Profile

Emmanuel Mbuba is a research scientist at the Ifakara Health Institute (IHI) in Tanzania, where he serves as a Deputy Head of the Vector Control Product Testing Unit (VCPTU). He leads several research studies on the evaluation of new vector control interventions including insecticide-treated bed nets (ITN), indoor residual sprays (IRS) and mosquito repellents. In 2017, he was appointed to lead the VCPTU’s Good Laboratory Practice (GLP) accreditation. In 2021, the VCPTU was awarded GLP accreditation for the efficacy testing of new vector control products. He is currently serving as a GLP Study Director in the VCPTU.

Mr Mbuba holds a bachelor’s degree in biotechnology and laboratory sciences and an MSc in molecular biology. He has several years of experience in the field of malaria and medical entomology. He is currently pursuing his PhD in epidemiology at the Swiss Tropical and Public Health Institute (Swiss TPH), where his research focuses on the field durability evaluation of piperonyl butoxide (PBO) ITNs and new methods for evaluating their durability in the field. He is interested in new vector control product development, evaluations and novel ways of testing and evaluating vector control interventions.

Emmanuel Mbuba is a Collaborator of the BRCCH project: ViALLIN: Visual Analysis of Long Lasting Insecticidal Nets to Maximise Universal Access. Read more here.

Seminar 04 June 2025 – Feasibility and economics of improved child deworming with albendazole-ivermectin

Seminar 04 June 2025 - Feasibility and economics of improved child deworming with albendazole-ivermectin

 

The BRCCH cordially invites you to join our seminar about feasibility and economics of improved child deworming.

When: Wednesday, 4th June 2025, 16:00 - 18:00 CET

Where:  Seminar room 4– Swiss Tropical and Public Health Institute, Kreuzstrasse 2, 4123 Allschwil

Registration: HERE
Directions and location information

Schedule:

      • Prof Jennifer Keiser, Prof Peter Steinmann, Prof Fabrizio Tediosi (all Swiss TPH) "Feasibility and economics of improved child deworming with albendazole-ivermectin"
      • Q&A and Closing

Speakers:

Prof Jennifer Keiser

Swiss TPH, Allschwil, Switzerland

Profile

Prof Jennifer Keiser heads the Helminth Drug Development Unit at Swiss TPH, which maintains a large and unique set of helminth-rodent models. She is also a Professor of Neglected Tropical Diseases in the Faculty of Science at the University of Basel. Her team’s research objectives include in vitro and in vivo evaluations of the biological activities of chemical compounds, assay development, preclinical studies such as pharmacokinetics and metabolism and clinical trials in helminthiasis-endemic countries, particularly in Côte d’Ivoire, the Lao People’s Democratic Republic, Russia and Tanzania. Prof Keiser holds a five-year ERC Advanced Grant and is leading a five-year multi-partner EU grant to develop new drugs against neglected helminth infections.

Prof Jennifer Keiser leads the BRCCH project: FACEIT: Feasibility and Economic Evaluation of Improved Child Deworming. Read more here.

Prof Peter Steinmann

Swiss TPH, Allschwil, Switzerland

Profile

 

Dr Peter Steinmann is a trained epidemiologist and public health specialist and holds a habilitation (associate professorship) at the University of Basel. His research interests include the epidemiology and sustainable control of intestinal helminth and schistosome infections; the impact of intestinal parasite infections on child health, nutrition and well-being; the transmission of Mycobacterium leprae and post-exposure prophylaxis for contact and the elimination and eradication of neglected tropical diseases (NTDs). He has a track record of work related to NTDs and public health in over two dozen countries over the last 15 years, including four years in China. He is currently deputy head of unit. His technical expertise includes NTD research and control programme implementation in China, Central and South-East Asia, Africa and Brazil, public health, WASH, health systems, data quality and surveillance and epidemiological surveys.

Prof Peter Steinmann co- leads the BRCCH project: FACEIT: Feasibility and Economic Evaluation of Improved Child Deworming. Read more here.

Prof Fabrizio Tediosi

Swiss TPH, Allschwil, Switzerland

Profile

Prof Fabrizio Tediosi leads the Health Systems and Policies group in the Department of Epidemiology and Public Health at the Swiss Tropical and Public Health Institute (Swiss TPH) and is a professor at the University of Basel. He holds a degree in economics and management from the University of Pavia, Italy, an MSc in health economics from the University of York, UK and a PhD in international public health from the University of Basel. He is an economist specializing in health policy analysis, the economic evaluation of priority setting, healthcare costing, the organization and financing of health systems, the economics of drugs, the economics of ageing and international development cooperation. His research interests also include universal health coverage, the economic and social implications of the elimination and eradication of neglected tropical diseases and global health governance.

Prof Fabrizio Tediosi co- leads the BRCCH project: FACEIT: Feasibility and Economic Evaluation of Improved Child Deworming. Read more here.

University of Basel Seeks Professor of Systems Developmental Medicine (open rank)

University of Basel Seeks Professor of Systems Developmental Medicine (open rank)

visual: University of Basel, Mark Niedermann

 

The Faculty of Medicine of the University of Basel, Switzerland invites applications for a Tenure Track Assistant Professor, Associate or Full Professor of Systems Developmental Medicine to be embedded in the BRCCH.

The BRCCH and its future Paediatric Digital Health Hub is a multi-disciplinary research centre creating new healthcare solutions for unmet medical needs related to communicable and non-communicable pathologies of significant burden to children and adolescents, irrespective of an individual's societal conditions.

Your position

The Professor of Systems Developmental Medicine will probe and integrate multi-omic data sets (i.e. genetic, epigenetic, transcriptional and metabolomic data) to create computational models defining the molecular signatures underpinning child development up to adolescence. By combining multidimensional molecular data with integrative computational methods, the professorship's research will contribute to a systems understanding of human development, mapping individual stages at single-cell resolution along an individual's health trajectory. This integrative approach will also define physiological variances of health trajectories and identify the developmental origins of disease states where age-specific, curative interventions and lifestyle adjustments can be implemented.

Your profile

The successful candidate will address gaps in our present understanding of paediatric system development and thus create an internationally competitive research program with an emphasis on clinical translation tailored to the specific needs of children and adolescents.
The selected post holder should have demonstrated an interdisciplinary academic work in Systems Medicine, that may include but it is not restricted to, the analysis of data at the molecular, cellular, tissue and organism level. Bioinformatic and/or systems-biological expertise is a requirement, whilst a clinical background combined with a profound molecular understanding of diseases is desired. Excellent academic performance and a proven record in acquiring competitive third-party funding relative to the applicant's career stage are essential qualifications. We expect a significant interest in student teaching and mentoring of junior scientists and the ability to create an attractive work environment that inspires creative thinking and mentors early career scientists and staff. Close collaborations are expected with clinical partners, scientists at the University of Basel, D-BSSE of ETH Zurich in Basel, all Departments of the Faculty of Medicine at the University of Basel and within the Basel life sciences cluster. Excellent communication skills are an essential attribute of a successful appointee.
Possibilities for qualified and accredited clinician scientists to be clinically active (20%) can be considered.

The university offers you

The University of Basel offers you a  unique opportunity to participate and shape interdisciplinary research related to child and adolescent health in a highly innovative and collaborative research environment.

The University of Basel stands out for excellence through diversity and is committed to equal opportunities, inclusive working practices and family friendliness.

Application / Contact

For further information, please contact the Chair of the Academic Recruitment Committee, Prof. Viola Heinzelmann-Schwarz (Phone: +41 61 265 90 99; Email: viola.heinzelmann@usb.ch) or the Scientific Coordinator of Academic Recruitment, Dr. Simone Neu (Phone: +41 61 207 61 64; Email: berufungen-medizin@unibas.ch).

Applications must be submitted by July 01, 2025.

We kindly ask you to apply exclusively via the online application platform of the University of Basel and as described in the application guidelines.

 

Dr Ece Özkan Elsen appointed as BRCCH Professor of Paediatric Digital Health Data Analysis

Dr Ece Özkan Elsen appointed as BRCCH Professor of Paediatric Digital Health Data Analysis

In July 2025, Dr Ece Özkan Elsen will join the Basel Research Centre for Child Health as a Tenure-Track Assistant Professor in Pediatric Digital Health Data Analysis. She will be affiliated with the Department of Biomedical Engineering of the University of Basel, where she will continue her research efforts on developing machine learning methods that are easy to interpret, fair, and generalizable for paediatric care.

 

Dr Özkan Elsen’s research focuses on computational models that integrate medical images, clinical data, and additional modalities such as physiological signals to support clinicians in the diagnosis and management of paediatric diseases. Specifically, she aims to tackle the main challenges affecting the performance of machine learning models, including data scarcity, variability across datasets from different sources and algorithmic bias. By integrating multi-modal datasets and drawing inspiration from human behaviour, she will develop interpretable artificial intelligence-driven healthcare solutions that will contribute to advance precision medicine for children and adolescents.

Further details about Dr Özkan Elsen’s research interests can be found here.

 

Seminar 03 March 2025 – OptiThyDose: Intelligent Digital Decision Support Tool to Personalise Dosing for Children with Thyroid Diseases

Seminar 03 March 2025 -Personalising Dosing for Children with Thyroid Diseases

 

The BRCCH cordially invites you to join our seminar about an intelligent digital decision support tool to personalise dosing for children with thyroid diseases.

When: Monday, 3rd March 2025, 16:00 - 18:00 CET, to be followed by an apéro

Where:  Seminarraum U1.191– Biozentrum, University of Basel, Spitalstrasse 41, 4056 Basel

Registration: HERE
Directions and location information

Schedule:

      • Welcome by Prof Marc Pfister (University Children's Hospital Basel, Switzerland)
      • Keynote by Prof Gabor Szinnai (University Children's Hospital Basel, Switzerland): "The clinical problem with thyroid diseases in children"
      • Keynote by Dr Britta Steffens (University Children's Hospital Basel, Switzerland): "The pharmacometric approach to solve the problem"
      • Keynote by Freya Bachmann (University of Konstanz, Germany): "The combination of pharmacometrics with optimal control theory"
      • Q&A and Closing
      • Networking Apéro

Speakers:

Prof Marc Pfister

University Children's Hospital Basel, Switzerland

Moderator

Profile

Prof Marc Pfister, MD, is a Professor of Pharmacometrics and Pharmacology in the Medical Faculty at the University of Basel, Chair of the Paediatric Pharmacology Department at University Children’s Hospital Basel (UKBB) and Head of SwissPedPha, the Swiss Platform for Pharmacology and Pharmacometrics Research in Paediatrics. He co-founded the American Conference on Pharmacometrics (ACoP) and the International Society of Pharmacometrics (ISoP). In the paediatric pharmacology research centre at UKBB, he leads a research group containing mathematicians, statisticians, engineers, pharmacologists and clinicians applying innovative pharmacometrics, control theory, machine learning and other AI-based approaches in order to develop clinical decision support systems with the goal of enhancing and personalizing treatments in neonates, infants, children and adolescents.

Prof Marc Pfister co-leads the BRCCH project: OptiThyDose: Intelligent Digital Decision Support Tool to Personalise Dosing for Children with Thyroid Diseases. Read more here.

Prof Gabor Szinnai

University Children's Hospital Basel, Switzerland

Talk: "The clinical problem with thyroid diseases in children"

Profile

Prof Gabor Szinnai is Head of Paediatric Endocrinology and Diabetology at University Children’s Hospital Basel (UKBB) and a research group leader in the Department of Clinical Research at University Hospital Basel. He trained in paediatric endocrinology in Basel and at L’Hôpital Necker – Enfants Malades in Paris, France. He is a board member of the National Committee for Rare Diseases (KOSEK) in Switzerland. His longstanding research interests are thyroid diseases in childhood with a special focus on genetic thyroid diseases and individualized pharmacotherapy for patients with thyroid diseases from birth to adulthood. He is a member of the Consensus Guideline Group for Congenital Hypothyroidism of the ENDO-European Reference Network (ERN) Initiative endorsed by the European Society for Paediatric Endocrinology (ESPE) and the European Society for Endocrinology (ESE). In 2012, he was awarded a Visiting Professorship Grant for Rare Endocrine Diseases by the ESPE.

Prof Gabor Szinnai co-leads the BRCCH project: OptiThyDose: Intelligent Digital Decision Support Tool to Personalise Dosing for Children with Thyroid Diseases. Read more here.

Dr Britta Steffens

University Children's Hospital Basel, Switzerland

Talk: "The pharmacometric approach to solve the problem"

Profile

Dr. Britta Steffens studied mathematics at the University of Konstanz, Germany, specializing in statistics. She has more than 12 years of university-based experience in statistical modelling, pattern recognition and data analysis, as well as (undergraduate) teaching. In 2020, she joined the Paediatric Pharmacology Department at University Children’s Hospital Basel (UKBB) as an interdisciplinary scientific researcher. Her main research topics are the analysis and modelling of clinical data in the context of developing decision support tools by applying mathematical-statistical methods and approaches from pharmacometrics and machine learning.

Dr. Britta Steffens is a researcher in the BRCCH project: OptiThyDose: Intelligent Digital Decision Support Tool to Personalise Dosing for Children with Thyroid Diseases. Read more here.

Freya Bachmann

University of Konstanz, Germany

Talk: "The combination of pharmacometrics with optimal control theory"

Profile

Freya Bachmann is a PhD student in the Department of Mathematics and Statistics at the University of Konstanz, Germany. In collaboration with University Children’s Hospital Basel (UKBB), she applies techniques from optimal control theory and numerical optimization to pharmacometric models in order to compute optimal individualized dosing regimens. In 2019, she received the American Conference on Pharmacometrics Trainee Award for outstanding research and gave an oral presentation of her work entitled “Computing the Optimal Individual Dosing Regimen with Constraints on Model States to Include Side Effects” at the main conference in Florida.

Freya Bachmann is a researcher in the BRCCH project: OptiThyDose: Intelligent Digital Decision Support Tool to Personalise Dosing for Children with Thyroid Diseases. Read more here.

University of Basel Seeks Professor of Paediatric Infectious and Emerging Diseases Modelling

University of Basel Seeks Professor of Paediatric Infectious and Emerging Diseases Modelling

visual: University of Basel, Mark Niedermann

 

The Faculty of Medicine of the University of Basel, Switzerland invites applications for a Tenure Track Assistant Professor, Associate or Full Professor of Paediatric Infectious and Emerging Diseases Modelling to be embedded in the BRCCH.

The BRCCH and its future Paediatric Digital Health Hub is a multi-disciplinary research centre creating new healthcare solutions for unmet medical needs related to communicable and non-communicable pathologies of significant burden to children and adolescents, irrespective of an individual's societal conditions.

Your position

The successful candidate will develop an internationally competitive research programme in Paediatric lnfectious and/or Emerging Diseases Modelling with an emphasis on clinical translation tailored for the special needs of children and adolescents. You will develop novel, integrative disease modelling approaches to investigate factors that influence disease development and outcomes in paediatric populations across different geographical and socio-economic settings, with special emphasis on low- and middle-income countries. Close collaborations are expected with clinical partners, scientists at the University of Basel and ETH Zurich in Basel, and within the Basel life sciences cluster.

The Master and Ph.D. programmes of the University's Medical and Sciences Faculties provide opportunities for teaching (in English).

Your profile

We expect from the candidate a genuine interest in interdisciplinary academic work and several years of experience in mathematical and computational modelling of health-related and epidemiological data. Experience with modelling of paediatric infectious and other emerging diseases is advantageous. Excellent academic performance and a proven record in acquiring competitive third-party funding relative to the applicant's career stage are essential qualifications. We expect a significant interest in student teaching and mentoring of junior scientists at different stages of their academic careers. Key personality traits include excellent social and communication skills and an open, engaging and collegial personality. The candidate's distinctive expertise, leadership, and outstanding communication skills place him/her in an ideal position to gain acceptance and trust. He/she is able to create an attractive work environment, inspire creative thinking that can be put into action, and encourage his/her employees.

The university offers you

  • A unique opportunity for interdisciplinary research in a highly innovative and translational research environment enabling access to patients and academic bioinformatics facilities
  • A challenging and varied job in a university and clinical environment
  • An innovative, interdisciplinary and open research environment
  • A responsible leadership role
  • A collaborative environment conducive to interdisciplinary research
  • Attractive employment conditions
  • Attractive startup package and endowment for research

The University of Basel stands for excellence through diversity and is committed to equal opportunities and family friendliness. In an effort to increase the proportion of women in professorships, the university is particularly interested in receiving applications from women.

Application / Contact

For further information, please contact the chair of the Academic Recruitment Committee, Prof. Ulrich Heininger (Email: ulrich.heininger@ukbb.ch) or the Scientific Coordinator of Academic Recruitment, Dr. Simone Neu Phone: (Email: berufungen-medizin@unibas.ch; Phone: +41 61 207 61 64).

Applications must be submitted by November 20, 2024.

We kindly ask you to apply exclusively via the online application platform of the University of Basel and as described in the application guidelines.

 

Dr. Na Cai appointed as BRCCH Professor of Computational Medical Genomics

Dr. Na Cai appointed as BRCCH Professor of Computational Medical Genomics

In February 2025, Dr. Na Cai will join the Basel Research Centre for Child Health (BRCCH) as an Assistant Professor of Computational Medical Genomics. She is currently leading a research group at Helmholtz Pioneer Campus at the Technical University of Munich, where she investigates the genetic bases of psychiatric disorders, particularly Major Depressive Disorder (MDD). This debilitating mental disorder manifests in a wide range of clinical symptoms, including depressed mood, anhedonia or sleep disturbance. In spite of its high prevalence worldwide, the strong polygenic nature of MDD and its heterogenous symptomatology hinder the identification of the biological factors causing this disease

 

Leveraging clinical and genomic datasets from biobanks and electronic health records, Dr. Na Cai and her group have developed a new computational and statistical approach to associate genetic variants with symptoms-based MDD subtypes (e.g. childhood depression vs late onset of MDD). In the future, she aims at developing new computational models to predict disease trajectories of MDD as well as examining the impact of MDD genetic factors in the context of other psychiatric disorders, such as attention-deficit/hyperactivity disorder, which often co-occurs with childhood MDD. Moreover, she will employ multi-omic approaches combined with machine learning methods to assess the impact of environmental risk factors such as childhood abuse or chronical social stress in individuals genetically predisposed to experience MDD.