PD Dr Sean Froese is a Principal Investigator in the Metabolism Division at University Children’s Hospital Zürich. His group studies inherited metabolic disorders, in particular those that affect folate and vitamin B12 metabolism. This encompasses investigation at the molecular level, including structural, biochemical and multi-omics approaches, combined with whole cell and whole organism studies. The group’s vision is to use this integrated approach and international collaborations in order to understand disease pathomechanisms, identify new therapeutic targets and have a meaningful impact on therapies for these rare diseases with unmet needs.